Summary
Detecting Genetic Abnormalities in Hematological and CNS Malignancies With Chromosomal Microarray Analysis Webinar
Date: Tuesday, September 10, 2024
In this webinar, Lina Shao, clinical professor of pathology and pediatrics at the University of Michigan, will discuss cytogenomic studies for detecting acquired abnormalities in hematological malignancies and solid tumors, focusing on chromosomal microarray analysis in B-cell acute lymphoblastic leukemia (B-ALL) and central nervous system tumors.
Attendees will learn:
- The important role of cytogenomic studies in hematological malignancies and solid tumors.
- The WHO-defined genetic abnormalities in B-ALL and essential genetic abnormalities in oligodendroglioma.
- How chromosomal microarray analysis (CMA) provides a whole-genome view and identifies intrachromosomal amplification of chromosome 21 (iAMP21) in B-ALL and 1p/19q co-deletion in oligodendrogliomas more accurately than targeted assays.
- The importance of CMA with an SNP component in distinguishing hyperdiploidy from masked near-haploidy or low-hypodiploidy, which have opposite prognoses in B-ALL.